About RBGB
Introduction to RBGB
Watch the video below where Leif Panduro Jensen (Former Chairman of the RBGB Steering Committee) and Estrid Høgdall (Chairman of RBGB and Professor) present RBGB
If you wish to know more about the individual biobanks in RBGB then please look at the descriptions below.
Organisation
Danish Cancer Biobank is a clinical biobank organized in six centers located in Herlev, Næstved, Odense, the National hospital, Aalborg, and Aarhus. The biobank centers coordinate the regional tasks and responsibilities: contact with the biospecimen collection departments, contact with researchers, biospecimen registration, freezer storage tasks, and biospecimen transfers.
Clinical data sources
Danish Cancer Biobank has its own national laboratory information management system (LIMS) which is linked to the clinical database, Patobank. This means that collected biospecimen can be complemented by diagnostic data. Furthermore, it is possible to connect the biospecimen to the civil registration number registry and the Danish Multidisciplinary Cancer Groups (DMCG).
Target Group
The target group for the collection of biospecimen for the Danish Cancer Biobank is patients with a cancer diagnosis. Tissue is typically in conjunction with surgery and blood samples are routinely taken immediately before any surgical procedure. But a lot of research projects are involved in the follow-up procedures where blood or other types of biospecimen can be collected.
Background
In “Cancer Plan 2” (2005) an infrastructure for clinical cancer research was recommended, which in 2007 led to the Ministry of Interior and Health establishing an infrastructure fund. Also, in 2007 a number of pathology and clinical biochemical departments collaborated on an application which led to the establishment of the Danish Cancer Biobank. In the Danish Cancer Biobank there is a national collection of biospecimen primarily for research but also to supplement Patobank with frozen biospecimens. From 2010 all Danish Regions became active as contributors of this collection. The Danish Cancer Biobank receives annual grants from the Danish Regions to cover their expenses running the biobank.
Perspective and Vision
The goal for the Danish Cancer Biobank is to strengthen the infrastructure for clinical cancer research and transfer biospecimens for supplementary diagnostics. This is effectuated through standardized sampling, that ensure a similar quality; trained staff, who process the biospecimen; good coverage of the many different varieties of cancer; a simple workflow for researchers who contact the biobank regarding their specific research project.
The Danish Covid-19 Biobank
In the frantic days of the Danish shutdown in March 2020 a lot of researchers realized that Bio and Genome Bank Denmark presents an exceptional opportunity to collect biospecimens and illuminate the various aspects of the epidemic. The practicalities of establishing the national clinical biobank were carried out on different levels: The biobank needed approval from the RBGB Steering Committee and the Regional Directors of Health, and studies of the disease needed to be planned. The importance of shedding light on the epidemic as thoroughly as possible was evident on all levels. The first samples were registered in the new biobank on the 25th of March 2020. Blood samples have been collected from healthy patients suspected of having Covid and patients with mild, moderate, and severe symptoms of Covid-19. Currently studies are utilizing the collected biospecimens to study Covid-19 antigens, antibodies, virus RNA, and other biomarkers related to diagnostics and prognostication of the disease. Multiple collaborative efforts have been established between various hospital departments and private actors. The efforts are characterized by information sharing and openness in order to know as much as possible as quickly as possible.
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About us
The Danish Blood Donor Biobank (DBB) collects and stores blood samples from donors who have agreed to participate in the research project, The Danish Blood Donor Study (DBDS). The inventory of the biobank consists of residual blood samples procedurally drawn as a part of donating blood. When a participant is included to the research project, a sample of whole blood is stored, and the DNA is purified for a comprehensive genetic analysis (Infinium® Global Screening Array (GSA), Illumina). An aliquot of plasma is stored at the time of inclusion and every time a participant donates, termed longitudinal samples. The longitudinal samples enable researchers to measure the change in biological markers over time.
The Danish Blood Donor Study (DBDS)
DBDS is a research project meant to provide new knowledge on the health effects of donating blood and insights into disease in the general population. DBDS was started in 2010 in the blood banks of the Capital Region and Region of Central Jutland. It has since become national and today DBDS has 130,000 blood donors and is the largest genetic control population in Denmark.
When blood donors choose to participate in the DBDS, they fill out an electronic form on phenotypes. Subsequently, they can be asked whether they will fill out new forms, continuously developed by DBDS. In addition DBDS has approval to use the registry data.
The Danish blood banks
The blood banks employ a well-trained and motivated staff who handles the daily registration of blood donors, the blood sampling, and the daily management of the blood banks. By using the blood bank infrastructure, The largest health scientific examination of healthy people in Denmark is carried out at a low cost creating a national research resource for research in public health, disease etiology, diagnostics and treatment.
Blood Donors Denmark
Blood Donors Denmark is responsible for acknowledging the 180,000 Danish volunteer blood donors. The organization is built around voluntarism and has 500 volunteer staff members working to secure a stable blood supply in Denmark alongside the five regional blood banks. For more information: bloddonor.dk
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